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Although we clearly do not have a definitive answer to the mechanistic basis of many if not most mental diseases, we know with certainty that neural activity is rooted in a complex interplay between brain architecture, neurotransmitters, and a variety of related processes and factors. Why is it so difficult to accept that abnormalities in how these processes work or interact is at the basis of many severe psychiatric diseases? I'm not saying that brain chemistry abnormalities are the cause of all our failings, unhappiness, and poor judgment, but I do believe that there clearly are people who very unfortunately have abnormalities in brain chemistry and that this has a big effect on their mental health. Schizophrenics are on an extreme of that spectrum.
Or perhaps behavior changes the brain chemistry. This is a kind of "which came first; chicken or the egg?" loop.