Your phrase “quickly figure out that humans were generally easy prey.” tells me that you are considering that Americans will continue to be disarmed by their servants in the agencies.
I doubt that.
If you are correct, then the Republic will be dead.
That situation was described by the noted historian, Paul Johnson. “If the American experiment in government fails, what will come after will be unspeakably worse.”
Between enviro-socialists in the agencies, and the crypto-communist administration we shall be under soon, consider emmigration - off planet.
I used the phrase “quickly figure out that humans were generally easy prey”, to specifically refer to a wolf-coyote hybrid. That blend is particularly scary, because it could be so intelligent and dangerous that it would be a threat even if you were armed and prepared. This is why I say that if such a cross is identified, it should be killed without hesitation.
I have seen both a 96% wolf dog and coyotes in action, and have a healthy respect for the capabilities of both. The social complexities and coordination that wolves use in pack hunting is as good as that used by a practiced light infantry squad, and traditionally, American Indians actually learned innovative tactics from coyotes. They had both respect for the animal, and the firm conviction that coyotes cannot be “trusted”, because they are both scheming and sneaky.
In the field, a wolf-coyote hybrid pack would have any number of advantages over a hunter. They would smell and hear him, and note his direction of travel far beyond the range of his rifle scope. They would encircle him and close the gap to his rear to just a few seconds at full sprint.
All of this assumes a hunter who is hunting. What chance would a person have who was doing anything else?
As was pointed out, many of these wild animals are losing or have lost their fear of man. When this happens, the typical response is to track down and kill the murderous animal. But this only works if it is just one animal, not perhaps hundreds, unless you try and eradicate them all.