#4 hardened shot has good cross-sectional area, but does not "reliably" penetrate (only 7 to 10") to depths that inflict enough damage on the target to be considered lethal, though I still wouldn't want to be on the receiving end. My guess is that you are concerned with wall penetration as well. #4 will certainly get someone's attention, but if you don't want them to get back up again use #1.
Now in old farmhouse [plaster walls, solid doors] with no nearby neighbors, so prolly time to change the requirements, especially regarding the availability and use of vests recently...
Hows that 00 'tactical' buck spoken of earlier compare with standard #1 shot ???