My 45s are of the Ruger Bisley Vaquero persuasion (got bit by the SASS bug....)
I also have a Smith & Wesson model 25-7 in 45LC, with unfluted cylinder, bull barrel and Hogue grips, that has the best trigger I have ever felt on any firearm.
I too got bit by the 45LC bug, and picked up a Ruger New Vaquero 4 5/8” with a Kirkpatrick leather rig. I fretted a little over the rudimentary, nonadjustable sights, until I realized that shooting a SA involves mental sights; you have to look into the cold, poker eyes of your adversary and will your hand to place the lead accordingly. Problem solved. It does take practice, at around $27 a box.