As stated by another Freeper, the Natchez Trace is an excellent drive. Several years ago I traveled to Memphis, and then drove farther west to the Civil War historic site Fort Pillow in Henning, Tn. Here's the link to the park:
Fort Pillow
From Memphis, Henning is North. It’s also the home of Alex Haily, who wrote Roots. A lot of the story was about Henning.