The only difference would be training drone operators as pilots.. even maybe operating the drones from another flying platform.. for recon or attack.. OR a mix of BOTH platforms.. Consider a couple of pilots(in f-35s and several drones(f-18s or something like that) as an air wing..
Lots ansd lots of options here.. Including mini attack drones.. for the battlefield.. Even LIMPET MINE drones to attach to enemy fighter airceaft.. to be blown up when the enemy pllot LANDS his aircraft or disattachs "later" for an other target......
The UAVs are not jets...so no spiffy high-g manuevers... and with their slow speed are not close to being dogfighter weapons.
They could, eventually, be a supplement to our piloted fighters....by being just dumb trucks to unleash a barrage of smart AMRAAM-NCADE's that will provide the major Air-to-Air capability of drones for the forseeable future.
Dogfights with a drone would be a turkey shoot. The piloted plane would be easily able to get inside the drones perception/decision loop...and always be several steps ahead of it.