Among the first projects, some of those (idiot) savants have in mind:
Creating an artificial black hole. You know, the kind that eat literally everything - even light.
Right here. On Earth. Just below ground level.
What could *possibly* go wrong?...
a) they could find out that the idea is mythical, and be made to look like fools;
b) they could discover that, like "artificial life," it cannot be "created" -- in fact, is an oxymoron.
c) they could short circuit the thing and create a 17 mile crater....
d)....
Cosmic particles still collide at much higher energies, so if the black hole catastrophe is possible it would have happened by now.