Reminder that if you see a 16-foot python in your backyard doghouse, get a machete and go to work!
The only lethal measure recommended is a long-handled shovel or hoe to kill the snake by severing the head from the body. DO NOT handle the head of a venomous snake alive or dead. A recently killed snake may bite by reflex action. Venomous snakes should only be killed if their presence endangers humans or pets. More than 80% of snakebites occur when a person is trying to kill or handle a snake. If the snake is encountered outdoors, the best defense is to back slowly away from it.
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Now, it would take a lot of work to sever the head from the body of a 16 foot python with a hoe. That said it would be exciting.