Kinda chuckling a bit ...
My own experience has been that actually having experience playing an instrument is a detriment to playing Guitar Hero. But full disclosure, after 5 minutes of GH, I’m thinking ‘I could pick up an actual instrument’.
My digitech rp3 has a play along feature ... plug in the iPod and off I go.
It depends on how long and how well you play the real instruments. Both of my now young-adult kids played in the shool orchestra from 3rd through 12th grade. They have an intuitive sense of rhythm, phenomenal hand-eye coordination, and even an understanding of song structure.