So I would be able to replace SpySweeper with Trend?
No, the Trend is just a secondary virus scan.
You still need something like SpyBot to get rid of spyware.
I often set SpyBot or Trend to run when I go to bed, as they take some time to scan everything.
In your case, you need extra strength protection from the DUmmies. I think you need some Trojan extra strength condoms for your computer, but I don’t think they make them large enough :)