I seem to have a chronic memory leak. I use SYSTEM MECHANIC 7 to slap it back into shape 1-3 times/day. How would that problem relate to folding?
To be honest, the memory leak could come from M$ Winders directly. Make sure that you have all of the most recent updates from M$.
However I bet is that the screen saver is the culprit for the memory leak. They are notorious for ignoring proper garbage dump protocols and running roughshod over Windows.