I'm gonna have to see if it's available on e-bay, because it's been years since I've seen it, but Peter O'Toole is great as the mad scientist, Mariel Hemingway is hillarious as the young woman in love with him, and Virginia Madsen is absolutely gorgeous. Like I said, it's a very off-beat comedy, but I loved it.
Looks like it's available at Amazon:
http://www.amazon.com/Creator-Peter-OToole/dp/1573625809/sr=1-1/qid=1172467969/ref=pd_bbs_sr_1/105-1153527-3514859?ie=UTF8&s=dvd