While Meyer does have Tim Tebow to fall back on if Leak starts making bad throws, I'd expect Ohio State to be able to defense him well, as most teams did toward the end of the season (unless, of course, Meyer has cooked up some new and inventive ways to use him). But he's still just a freshman, which means that he can't be expected to be able to carry the team all on his own. In a year or two, yes, but not right now.
I'm going to be rooting for Florida, of course, and win or lose I'm going to be very happy with this season and looking for the Gators to be really dominant next season. But if I had to put money down, I'd have to pick Ohio State to win and to cover the spread.
Prediction - Ohio State 31, Florida 21.
That's the uncertainty: the novel offenses and defenses that pop up for bowl games.