I wouldn't count piracy as a problem most people will experience with Vista. Most people switch operating systems only when buying a new PC, so they won't deal with that.
They will deal with a flood of attacks on Vista's new network stack, though.
Sure they will have problems related to this.
Wait until Microsoft decides to make everyone revalidate their OS loads. You know there will be a screwup or three in that process so people who legally bought the OS will end up being denied full operability of it.
I wish I could post the eweek.com story I found.