I carry one of those Airweights and practice with a glove.
I'm not too worried about the sting to my hand if I shoot someone. However if you can't recover from the first shot that is a different matter. But you can find that out with practice practice practice.
I practice with gloves also.I know the sting would not bother me in a self-defense situation. Its the shooting practice that gets to me. (100 rounds thrown out and my hands get tender)