The only 'big city' club I ever got to was the Cameo Theater down in Miami, mid 1980s. The ladies rooms had broken windows that looked out over Collins ave (way before South beach became hip), two inches of standing "water" on the floor and the toilets hadn't been flushed in ten years. Pretty horrific, but the memories remain.
Saw the Damned, Stray Cats, Ramones and The Clash back then--but most of the great bands didn't venture that far south back then.
I did manage to make it to some of the clubs in London when I was a student -- not the same, of course.
I literally lived at CBGB's in the 70's.
It was a short subway ride from my Brooklyn apartment. I would come home from school on Friday, do homework and go to sleep. Would wake up at 11:00, shower and meet my friends on Avenue X.
If it was summer, we would get home from the city at 6:00am, catch some breakfast and off to the beach.
My favorite act at CBGB's? Johnny Thunders, RIP.
It usually involved somehow managing to have three functioning hands when you normally only have two.