"To see the real-world evolutionary importance of built-in biological mechanisms of genetic change, we have only to consider the post-WWII emergence of multiple antibiotic resistance in bacteria."
Makes you wonder how earlier life thrived with no knowledge and no ability to kill bacteria, yet man can lose millions of people with just one flu virus. And man has the ability to at least partially cure himself. Dinosaurs went millions of years, and had no intelligent ability to heal, and yet survived until wiped out by an outside source. It is almost like man is causing bacteria to "hurry" and find new pathways of survival. Which may actually lead to his demise.
I have often said that man has interfered with his own evolution with the implication that he better be successful in engineering a better human or he will get extinct pronto.