I agree with the idea that this was probably as much about the danger of writing while high, as it was about Oprah.
But the people I feel most sorry for are any new viewers that watched this one because of all the hoopla over the last episodes. :-)
"Honey... is that a gun in oprah's... uhmm..."
"I think so."
"...and it's talking...?"
"Yes, that's what it looks like."
"why?"
"I don't know, hon... maybe we should watch Family Guy instead..."
"but why would they do..."
"I don't know... I really don't..."
Heh... Not to mention the other character is a stoner towel.
The regular characters weren't in this episode at all. No kids, no South Park.