I've read several articles that vitamin D is actually preventive against some kinds of cancers including skin cancer. This has caused a real dilemma for those who advocate lots of sunscreen. Here's the link to an article: http://www.msnbc.msn.com/id/7875140/ I imagine that if I lived there where there was little or no protection against UV from the ozone layer, I would be more careful, too. But up here in the north, I don't worry about it. Between the clouds and staying indoors for so much of the winter, I don't think we're exposed to enough during the rest of the year to worry about, but that's just my opinion.
The hole seems to be shrinking:
http://news.bbc.co.uk/2/hi/science/nature/1050495.stm
Note that they directly attribute this to the global ban on PCB's. If we start making these chemicals again, the effect will reverse.