http://www.snopes.com/photos/bushbook.asp
"Origins: This may be a funny picture, but even if were real, it would still be just a funny picture.
The photo does show some tell-tale signs of digital editing, so the real explanation is that someone took an existing picture and flipped the image of the book in President Bush's hands. Note, for example, that the picture on the back of the book in the student's hands and the one on the back of the book President Bush is holding are the reverse of each other, a dead giveaway that the photo was manipulated:"
Also note that there is writing under Mrs.Cheney's picture on the back cover(lower pic). That writing is missing in the manipulated upside down pic.