That was the best individual season in NBA history, but Chamberlain was a 7' 1", 260 pound center in a league full of 6'7", 230 pound centers. For the longest time, Boston's Bill Russell was the only serious defensive threat Chamberlain faced.
A buddy of mine saw Wilt at a pickup game in '79 at Pauley Pavillion (six years after he retired from the league). Also playing in that game was a youngster who'd just been drafted by the Lakers by the name of Earvin Johnson. Wilt not only schooled the kid, he dominated him, blocking countless shots by Magic attempting to score down low and grabbing every board in sight.
Wilt would've dominated in any era, although certainly not to the extent he did in the early 60s.