Sure! Magic becomes science - all very sinister, of course. Take Snow White. Evil stepmom could be the ceo of a cosmetic's firm. Her PR department thinks Snowie would be the better "face" for the company. Stepmom hires a hitman and snowie goes into hiding in some exotic locale. The dwarves could be anyone from homeless teens to Mexican day laborers or heck, even real miners. She cooks and cleans all the live long day.
Now, the prince could be the VP of the company who swings into action to find and rescue her before the hitmen find her.
Etc....