No, they are nominated and confirmed to a specific position.
Think of it as analogous to Bolton and his nomination to be UN Ambassador. Once confirmed, he will not have credentials to negotiate with, say, the United Kingdom, and the UK Ambassador will not be able to argue the position of the United States before the UN, nor can they be swapped after confirmation. That would be a new nomination, requiring new consent.
BTW - Tomorrow I think I'll write about advice and consent. I sense it coming on.
Have you seen that Lindsey Graham has expanded on the Memorandum of Agreement by verbally stating on national television that they (the gang of 14) will have a lot to say about Social Security as well?
The tyranny of the gang of 14 continues; now they think they are running the country. And without intervention, they just might.