How to block Drudge popups:
http://www.jesush.com/index.php?p=825
You may want to drill down through the links on that page and read the related threads as well, depending on how interested you are in learning about alternate methods of blocking.
I understand popup's are annoying, but don't you think if you are going to view Drudge's content you should follow his rules. What is Drudge's incentive to provide content if he can't make money off of his site?