In my mind, I pictured the fictional Dupont as Duke.
Does Buster Roth have any correlation to Coach K? I hope not! The Dupont of the book also made me think of Duke, but Wolfe has stated it's an amalgam in order to get the right academic / athletic mix.
Wolfe went to Washington and Lee. So did I. I can guarantee some of the the fictional college came from his experiences there.