Spy Sweeper works well for me.
Also, stay away from the Drudge site. Pop-up city, and all the spyware known to man.
I finally took Drudge off my bookmarks so I wouldn't accidently go there.
I visit Drudge all the time and have no problems.
You need to run Ad-Aware SE Personal 1.05 (free), Spybot Search and Destroy, and the related Spyware Blaster. Also occasionally run CWShredder. And I swear by Ad Muncher, which blocks popups and banners. Most of the spyware either comes from visiting porn or music download sites or from advertising links that have been hacked. Ad Muncher blocks a lot of that and saves time loading sites too. It costs a bit but is well worth it. Very clean, well-designed, and small footprint.