I'm diggin' Mozilla. So much love.
Don't forget about CoolWebSearch. Search for CoolWebShredder to get those.
Also, web-browser hijacks, which make spyware data miners seem tame, can be taken out; though it takes a higher level of competance.
Grab a copy of HiJack This! and head to http://www.techsupportforums.com and post your HiJack This log to the Spyware/Virus section and the vets will help you fix what's broken. I don't recommend trying to fix the logs yourself if you aren't computer savvy.
I used the Ad-Aware + Spybot combo on my mothers computer and found over 900 pieces of spyware...deleted them all, switched to Firefox, and haven't had a problem since.
Here's the direct link:
http://www.techsupportforums.com/forumdisplay.php?f=50