I didn't realize that they are almost always male. My family had an orange cat once that was a female. She was the sweetest cat anyone could ever have. She loved to be picked up and held - and would even let children hold her. She never bit anyone, and I never heard her actually cry until she was dying from cancer.
When my vet was explaining about the orange gene being predominantly male, I think she said something about their dispositions too. You wouldn't think (I didn't) that a "mutt" type of kittie would have a certain disposition. At any rate, they are known to be sweethearts :) Sorry to hear about the cancer... how old was she?