My interpretation of your quote is that she is saying Kerry cannot win. But I have no context other than the one you offered. I don't even know if she is conservative or liberal.
Laura is a conservative. She's throwing a dose of cold water on over optimism the President will win this one easy. He has his work cut out for him. Up to now the WH has been sitting it out on its hands. That will have to change if the President wants to be re-elected in November.