One is for the TV that you see in the picture, one is for the VCR, and one for a DVD.
I also have my Monitor set up as a TV/Satellite receiver and can play VCR and DVD thru it. I often use it in place of the TV as I can capture stills, record or make movie clips with anything that I show on my Monitor.
I have a combo VCR/DVD set up to the right of the monitor. So I have one remote for the combo set up and one for the Monitor. The little black thing you see taped to the monitor with red tape is the electric eye for the monitor remote that is if I dont want to use the mouse or the keyboard.
Five remotes in all, a guys paradise.
We have 5 remotes in the living room - 1 for the tv, one for the dish receiver, one for the dvd player, 1 for the vcr, and 1 for the amplifier. It's always a challenge to keep them where we can find them.