[raynearhood]

Pangenes were what Darwin insisted (but could not prove) is the method by which evolution occurs. Genetic research was pretty young back then. Pangenes could not be observed due to lack of proper tools. However, they could not not be observed due to lack of proper tools, also. Better genetic researh than what was available during Darwin's proved that pangenes do not exist.

And so died Darwinism.

And so was born neo-Darwinism, otherwise known as the belief that evolution occurs with beneficial mutations as the method by which it occurs.
To have enough beneficial mutations occur in sequence to develop one simple adaptation (i.e. a lizard replacing its scales with feathers on the long road to becoming a bird.) is mathematically impossible. Scientist know this. So how is the problem explained?
Time.
Over a short period of time (say 100,000 years) it's mathematically impossible. But over billions of years it can happen. That is called extrapolation beyond reason.
It can't be observed due to the lack of equipment(like a time machine?). However, it CAN'T NOT be observed due the lack of equipment.

So... It's the pangenes, Stupid.

[neverdem]

So... It's the pangenes, Stupid.

Bear with me, the hour is late. I believe you're saying Darwin is/was correct. I hope so because natural selection from random, natural mutations explains the antibiotic resistance of formerly sensitive pathogenic organisms after exposure to a previously lethal antibiotic, i.e. to the organism, if the patient finished the prescription, e.g. a patient didn't finish the complete course of treatment prescribed by the physician because the patient started to feel much better and didn't finish her/his medicine.