Resigns from her seat in the House?
This is a long-time story. Pelosi planning to become Ambassador to Italy. I seem to recall the story was first floated in 2020, and widely reported again last month.
She will retire but take her seat with her. When she passes away it will be buried with her. Her district will just not be represented except during seances when other Democrats want to get a feel for how many on the other side will turn up on polls.