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Isn’t it amazing that HCQ, Ivermectin, and Pfizer’s PAXLOVID ($72per pill) all inhibit the same SARS 3CLpro enzyme to inhibit replication?
twitter ^ | Nov 11th, 2021 | Clarke MD

Posted on 11/12/2021 9:09:51 AM PST by Mount Athos

Weird that two are “snake oil” and the expensive one will get EUA {Emergency Use Authorization by the FDA}


TOPICS: Health/Medicine
KEYWORDS: 72bucksapill; chinavirustreatment; covid; hcq; hydroxychloroquine; ivermectin; paxlovid; pfizer; pfizermectin; sars3clpro; sars3clproenzyme; waronivermectin
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To: Mount Athos

Ignore the government and become lawless like them. Turn the spigot back on.


21 posted on 11/12/2021 11:34:52 AM PST by Irenic ( )
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To: high info voter
Re L-Lysine. My Cv-19 folder has some 1200 items mostly just Web links but I did read - maybe WebMD that said (I think) that Zinc may interact with the lysine.

All I can find is that if one is supplementing with calcium for say osteoporosis its a consideration. Also some gut drugs.

See Drugs.com - Lysine (Search on "What other drugs will affect lysine")

Not a Doc. ;-)

22 posted on 11/12/2021 11:35:25 AM PST by Tunehead54 (Nothing funny here ; - )
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To: Mount Athos

No. I have read a fair bit on the subject and took 600 level virology and epidemiology many years ago. I freely admit that I have forgotten much of it, but given that I was at the top of my class I had some aptitude or competency on the subjects once, but I don’t claim any current expertise beyond spending time researching on my own with competent studies.

HCQ’s primary benefit against Covid is as a zinc-ionophore. The other action of the drug dealing with pH and lysosomes does not appear to affect SARS. The anti-viral mechanisms of zinc are well understood and documented. By increasing cellular uptake of zinc we reduce viral replication by blocking the RNA polymerase. Some of the early studies on HCQ that showed no benefit ignored zinc.

The research also shows that HCQ was minimally effective in a patient who already had a high viral load. These were the studies that the CDC used to poo-poo HCQ after Trump mentioned it. Based on my research, HCQ needs to be administered early to work and it also requires adequate zinc.

The protease inhibitor (IVM and mulnoprovir) blocks replication of the virus via direct action instead of improving uptake of zinc. I firmly believe that IVM will be just as effective as the “new Pfizermectin” with a much cheaper cost.

There is much debate about the adequate level of zinc supplements. Based on what I have read and researched my family has been taking quercetin with zinc as it also produces the ionophore benefit although I believe HCQ is more powerful and effective.

You can get the same result with a protease inhibitor or a zinc-ionophore but the more effective of the two by itself appears to be IVM. The direct mechanisms are different but essentially both can provide a benefit as long as there is adequate zinc They did not incorporate both mechanisms in the pill, which to me is an admission that the protease inhibitor is most effective.

This debate will not be settled any time soon, but what is clear to me is that we should have been employing an early treatment plan using both (safe) aggressively upon onset of symptoms along with other cheap supplements like vitamin D.

There is no doubt in my mind that many lives would have been saved and illness would have been minimized for millions. I think in the coming years people are going to be very angry when they comprehend the truth of the last 18 months.

PS - I don’t claim and will not claim any “authority”. With a few hours of effort people can research this stuff for themselves.

I am not snarky and don’t come here to argue with anyone nor do I care if we don’t all agree with one another. We all have opinions and can live with the results. However, I am not clear what your disagreement is with what I wrote. This author is the first one who lumps them together when there are clear differences to me in the mode of action for HCQ and IVM or Mulnoprovir as described. Mulnoprovir appears to be a variant of IVM.

While I believe based on my own research that IVM is most effective, I do believe that HCQ administered early improves outcome. I have not read anything that says Mulnoprovir has any similarity with the chemistry of HCQ.

This may simply be a matter of semantics. Both do the same thing via different mechanisms, but the original source here appears to indicate that the new drug is similar to HCQ. It is not from what I have read. Again, same result via a different mechanism and I firmly believe IVM is the more effective (far more than the vaccines!).

FReep on FRiend.


23 posted on 11/12/2021 11:55:06 AM PST by volunbeer (Find the truth and accept it - anything else is delusional)
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To: high info voter

L-Lysine appears to be effective. I just started reading about it a few weeks ago.

Famotodine also shows good effect (Pepcid).


24 posted on 11/12/2021 11:57:16 AM PST by volunbeer (Find the truth and accept it - anything else is delusional)
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To: volunbeer

You’re talking as if a drug being a “zinc ionophore” and a ‘protease inhibitor” are altogether two different things.

Zinc is a protease inhibitor.

You are drawing a false distinction.


25 posted on 11/12/2021 1:27:27 PM PST by Mount Athos
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To: Mount Athos

Zinc needs help to be most effective as an anti-viral.

It’s not just me saying this, it is many doctors who have promoted aggressive treatment of Covid vs “supportive care” or the wait until your lips are blue and go to the hospital crowd in charge.

https://www.prnewswire.com/news-releases/studies-show-zinc-inhibits-viral-replication-but-theres-a-catch-301079772.html

Regarding the original piece for which this thread was started it appeared to me that the good doctor was equating all three. The pfizermectin “new and improved” treatment appears to be a copy of IVM and it does not appear to be the same chemically as HCQ or the same by mode of action as HCQ against coronavirus.

It’s not that big of a deal to me so we can agree to disagree about whatever your disagreement was with what I wrote. I do believe HCQ is a good tool against coronavirus based on what I have read and studied if it is accompanied by zinc supplements or the appropriate amount of zinc in the body AND it is administered early.

I firmly believe that IVM is the BEST tool against coronavirus.

I guess if his point was that Pfizer is floating something that is no more effective and much more expensive he is spot on, but I view the two drugs as being very different.

Unless I have completely missed something (certainly possible), it is not HCQ itself that is effective against the coo. It is how HCQ allows zinc to act that is responsible for its efficacy.


26 posted on 11/12/2021 1:37:20 PM PST by volunbeer (Find the truth and accept it - anything else is delusional)
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To: Irenic
"Ignore the government and become lawless like them."

Hey, it's only business!

If painted into a corner, I would like to think I could become their worst nightmare. But, alas, I am but a helpless old man.

27 posted on 11/12/2021 4:37:13 PM PST by The Duke (Search for 'Sydney Ducks' and understand what is needed.)
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To: volunbeer
Such a total failure to the people of the world. Preventatives are there... CURES are there.... and the numbers have been purposely expanded to make money for the elites.

SO SAD for all those who have died!

28 posted on 11/13/2021 3:48:16 AM PST by high info voter
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To: Mount Athos
I've been thrown in Facebook jail 6 times in the last year and a half for sharing truth from licensed medical and scientific experts on the drugs available to kill off this Covid BS.... The world is being totally SCREWED!!

Here's another one "L-Lysine"..... 100 tablets $3.49 at Walmart.... kills it off quickly. Check it out....

https://principia-scientific.com/a-cheap-new-covid-cure-just-did-away-any-need-for-a-vaccine/?fbclid=IwAR2s2UHwQ5G3VIq1ge4SW0veeSvy9LpbQBqWHPVYi7utbEi3VlKXUDCvsbs

29 posted on 11/13/2021 6:29:38 AM PST by high info voter
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To: high info voter

SO SAD for all those who have died!


There is going to be a lot of anger. A lot.


30 posted on 11/13/2021 8:00:14 AM PST by volunbeer (Find the truth and accept it - anything else is delusional)
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To: Ymani Cricket

This is how they tricked people into getting Paxlovid -early memes and jokes about how Paxlovid was actually Ivermectin. People (probably bots) were sneering that Paxlovid was actually ‘PFizermectin’ meant to scam money off of those who would otherwise get low cost HCQ and Ivermectin.


31 posted on 12/01/2022 3:54:19 PM PST by ransomnote (IN GOD WE TRUST)
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