May indicate recent immunity or immunity from a similar virus years ago.
Doesn’t tell you of T-Cell immunity.
Seems to me that you’d need a second test weeks apart to see if there’s rising in the antibodies.
If you have a positive test result on a SARS-CoV-2 antibody test, it is possible that you have recently or previously had COVID-19. There is also a chance that the positive result is wrong, known as a false positive. False positive tests may occur:
• Because antibody tests may detect coronaviruses other than SARS-CoV-2, such as those that
cause the common cold.
An antibody test looks for the presence of antibodies, which are our body’s response to infections. Following vaccination, COVID-19 antibody tests will be positive. This does not mean you have had an active COVID-19 infection.
SARS-CoV-2 Semi-Quantitative Total Antibody, Spike
TEST: 164090Test number copied CPT: 86769
Updated on 08/17/2021
On May 19, 2021, the FDA issued a safety communication reiterating that “antibody testing should not be used to evaluate a person’s level of immunity or protection from COVID-19 at any time, and especially after the person received a COVID-19 vaccination.”
Per Quest Diagnostics
Quest Diagnostics
SARS-CoV-2 Antibody (IgG), Spike, Semi-Quantitative
Clinical Significance
SARS-CoV-2 Antibody (IgG), Spike, Semi-Quantitative - This test is intended as an aid in identifying individuals with an adaptive immune response to SARS-CoV-2 (COVID-19), indicating recent or prior infection.
The results of this semi-quantitative test should not be interpreted as an indication of degree of immunity or protection from reinfection.
Individuals who have been vaccinated with a SARS-CoV-2 spike or receptor-binding domain vaccine may be positive with this test; however, the clinical significance of a positive antibody result for individuals who have received a COVID-19 vaccine is unknown, in part because the test’s performance characteristics have not been established for that population.
It is not known how long antibodies persist following infection and if the presence of antibodies confers protective immunity.
It is yet undetermined what Antibody level is correlated to immunity against developing the COVID-19 infection
A numerical value will be reported up to 2,500 U/mL. For patients testing higher then 2,500 U/mL, your results will be reported as “Greater Than 2,500 U/mL.”
https://pubmed.ncbi.nlm.nih.gov/33483360/#&gid=article-figures&pid=fig-2-uid-1 <— 5 patients tests of U/ml post infection on a time scale to get an idea why it doesn’t mean a whole hell of a lot other than you have some degree of natural immunity if it is not a false positive.
My gut feel: If you have not had the vaxes and you were not symptomatic when you had COVID, bully for you. Your body mounted a highly effective defense and you should celebrate your luck in the genetic lottery. You are part of the population where COVID is a mild cold and not life threatening pneumonia. The fact that your levels are not particularly high but substantial, at least in my estimation, intuitively means your antibodies are very effective in squashing COVID.
Oh, and if you have been vaxed it means bubkis. It means you have been vaxed. It says nothing about immunity level. It means you have an antibody for COVID19 alpha variant spike protein and nothing more. Means there are antibodies to the alpha variant spike protein but nothing for beta, gamma, delta, mu, etc. unlike the recovered who have antibodies to literally hundreds of parts of the virus and almost certainly have some level of immunity to the variants.
This is something that the good for nothing, do nothing, NIH should have been developing. These people have been a complete waste thru out this whole pandemic.
Lab Corp does different tests.
This looks like the total anti-Covid IgG, which is directed at whole viral (e.g. nucleocapsid) antigens as well as Spike antigens. The early generation test may have cross reacted with immunity to endemic coronaviruses to some extent, but I don’t know about this particular assay.
I don’t order this test any more, but if my memory is correct, Negative is defined as <0.99.
Thus, your result would be considered a “high positive.” It suggests that you had a brisk immune response to either natural infection or immunization.
Currently, all the commercial labs will do more specific semi-quantitative testing: anti-Nucleocapsid IgG (natural infection-derived immunity) and anti-Spike IgG (natural infection and/or vaccine immunity).
The problem with interpretation is that no clinical data have been developed that correlate a given level of immune response (as measured in a test like this) with actual immunity to re-infection.
In contrast, such data DO exist for diseases like measles, mumps, chicken pox, Hepatitis A and B - thus, we can do “immunity screens” for those diseases and know if a patient needs those vaccines or not.
It’s why I believe I had a mild case but will not test for antibodies- my system will either protect me or it won’t and since they can’t tell shit from Shinola with the bug tests, how an we trust the antibody tests?
Wonder if you’ll now qualify for a Covid passport or be able to keep your job, or take your family out for a meal?
Antibodies don’t matter. You still must surrender to the shot.
It’s not about a virus; it’s never been about a virus.
Actually, if you have had any of the "Spike Protein Vaccines" that WILL produce a positive result on this test, but does NOT necessarily indicate you have actually had Covid-19.
I had the same test from LabCorp, with "negative results", and a similar one from Quest, also negative. (Both "Semi-Quant Total Ab")
They CLAIM: Can I use a semi-quantitative COVID-19 antibody test to determine my level of immunity?
A semi-quantitative antibody test can help identify individuals who have developed an immune response after exposure to COVID-19 or vaccination. However, it should not be used to determine the level of immunity you have. However, evidence is still being collected to determine if antibodies provide protective immunity against SARS-CoV-2 (COVID-19) specifically. Follow up with your healthcare provider for additional guidance on how to interpret your test results.
Actually neither of these test for immunity (antibodies resulting from recovery from prior infection), but it turns out that neither of those tests look for“Qualitative detection of high affinity antibodies to the nucleocapsid (N) protein of SARS-CoV-2"
1: I understand from a Consumer Labs review that labcorp offers the Abbot SARS-CoV-2 IgG nucleocapsid 100% sensitive 99.6% specific or the Roche Elecsys Anti-SARS-CoV-2 IgG nucleocapsid 100% sensitive 99.8% specific. I assume either one of these may be the labcorp SARS-CoV-2 Antibodies, Nucleocapsid 164068, which is really the test I expected to receive in accordance with the description shown above. Specifically, that “If you have been exposed to the virus that causes COVID-19, your body typically produces antibodies as part of the immune response to the virus.”
2: It turns out that the test I got was labcorp test number 164090, which specifically tests for antibodies to the spike protein produced by the vaccine, which I do not have, as I have not been (nor plan to be) vaccinated. It also comes with a specific disclaimer, as follows:
“Values generated with this assay cannot be used to determine whether or not an individual has developed protective immunity against infection and cannot be directly compared to other assays until a universal standard is established for assay calibration.”
3: It is therefore clear that this test (164090) is not appropriate for the purposes stated above
The intended use of 164090 is: “Semi-quantitative detection of high affinity antibodies to the receptor binding domain (RBD) of the spike (S) protein of SARS-CoV-2. Intended for use as an aid in identifying individuals with an adaptive immune response to SARS-CoV-2 indicating recent or prior infection. This assay also can be used to detect antibody responses induced by currently available SARS-CoV-2 vaccines.” “Values generated with this assay cannot be used to determine whether or not an individual has developed protective immunity against infection and cannot be directly compared to other assays until a universal standard is established for assay calibration. Results from this test should not be used as the sole basis to diagnose or exclude active SARS-CoV-2 infection”
I actually need labcorp test 164068, which should properly answer the above stated purpose for getting this test.
The intended use of 164068 is: “Qualitative detection of high affinity antibodies to the nucleocapsid (N) protein of SARS-CoV-2. Intended for use as an aid in identifying individuals with an adaptive immune response to SARS-CoV-2 indicating recent or prior infection. This assay can be used to differentiate between antibodies elicited due to natural infection versus vaccination.” Additional limitations of 164068 is: “This assay will not detect antibodies elicited by currently available SARS-CoV-2 vaccines.”
I had my doctor order LabCorp provide this more appropriate test (164068) for my needs.
There is more detail in this prior post from me in an earlier thread.