[Red Badger]

For those who don’t:

https://en.wikipedia.org/wiki/Hereditary_haemochromatosis

[Erik Latranyi]

I have the genetic markers and high iron from hemochromatosis.

The “stop eating red meat” and dietary suggestions are nonsense.

Your body is going to store iron from whatever sources it can find. Giving it less iron is not going to stop the retention.

I donate blood every 8 weeks and this keeps my iron in check. That is the typical treatment, but my blood is valuable (O+) and I would rather donate it for someone’s use than let the hospital take it from me and throw it away.

[ConservativeMind]

Something that is available and might be worth looking into, from the organ-saving side (in normal, small doses):

Researchers find potential cure for deadly iron-overload disease
https://medicalxpress.com/news/2020-09-potential-deadly-iron-overload-disease.html

4 Potential Uses of Ebselen + Side Effects & Dosage
https://selfhacked.com/blog/ebselen/

It sure doesn't sound like a cure, as the researchers state, but it might slightly reduce the long-term damage.

[spacejunkie2001]

you’ll get alot of info from earthclinic. here’s the link to their thread on hemochromatosis

https://www.earthclinic.com/cures/hemochromatosis.html

[nagant]

I research hemachromatosis a few years ago because I was interested. Hemochromatosis seems to be an upstream failure of the hepcidin/ferroportin system. Tissue thrives on iron bound by hemoglobin, but free iron in the blood is toxic to tissue. It causes liver inflammation. A healthy body also produces ferritin to safely bind iron. The liver responds to iron inflammation by releasing hepcidin. The hepcidin curtails the action of ferroportin. The cells lining the small intestine use ferroportin to transport food iron into the bloodstream, so curtailing ferroportin curtails introduction of food iron into the blood. One problem in this system is that all cells use ferroportin as an iron transporter. So iron
toxicity can wreck havoc with cellular oxygen uptake. It’s a complicated system where lots of things can go wrong.

[nagant]

One of the most common failures of hepcidin/ferroportin system happens when an autoimmune response to food and bacteria causes the small intestine to release zonulin. Zonulin causes the “tight junctions” between intestinal cells to separate, allowing intestinal lumen directly into the bloodstream. This lumen includes food iron. The zonulin reaction bypasses the hepcidin/ferroportin system, and floods the blood with free iron. The liver responds with more hepcidin. The intestines release more ferroportin, but the leaky gut prevents curtailment of iron uptake. However, in other cells the added hepcidin curtails ferroportin and iron uptake. Oxygen use gets restrained, and the victim tires easily.

[TTFX]

I would just remove blood and eat whatever I want.

If blood ferritin is less than 70 ng/ml, the person has an iron deficiency.