'Keep it simple' is very often the best approach. However, life is not always predictable (if it were, we would all have invested every penny we had in a winning stock, and be retired right now). If you go "all in", and there is no alternative (no 'Plan B'), it is possible to find yourself standing there, asking, "What do I do now?"
(Ask me how I know... ;^)
That's the whole point of having multiple firearms in just five or six common calibers. For instance:
Two ARs in 5.56/.223
One 7.62/.308 battle rifle
Two 9mm handguns and one 9mm carbine
Two .40 cal handguns and one .40 cal carbine
One 12 gauge shotgun
One .22 rifle
As you can see, there are eleven firearms, but just six calibers - all of them very common. One could have multiple back-ups in all six of those calibers. The above example is just a garden variety collection to illustrate the concept of redundancy.