Newly discovered painkiller could replace addictive opioids

Spectator Health ^ | August 17, 2017

[E. Pluribus Unum]

At one time Ecstasy was a miracle drug.

[ButThreeLeftsDo]

I’m dealing with a fractured shoulder.

Send me a sample.

;-)

[Governor Dinwiddie]

Maybe, maybe not. But announcing it is a good way to gin up some grant money.

[wastoute]

Anything that acts at an option receptor is going to produce addiction. Anything. Even electrical stimulation. Anything that acts at a receptor that augments stimulation at an opiate receptor is going to produce addiction. Heroin was the cure for morphine addiction. Methadone was the cure for heroin addiction. I can run down a list of “balanced” receptor agonists that were supposed to be safe, the most recent Ultram. All fantasy.

[cherry]

oh, no...they’re going to take the opiods away from freepers...what will we do....what will we do..

[NorthMountain]

I had a broken clavicle, aeons ago ... I know what you’re talking about.

[shibumi]

Walk a mile in my shoes ... oh wait - you couldn’t.

[2ndDivisionVet]

So was Laudanum.

[nitzy]

I wonder where they make UKH-1114? We’ll probably end up fighting a 20 year ground war there to control it.

[WatchungEagle]

Has anyone done this yet? If it gets you high, it’s gonna be addictive. When people try it and can testify it’s non-psycho active like aspirin or ibuprofen, then let us know.

There have been many of these false hopes about replacing opiates, both drugs that were addictive themselves and ones that didn’t work very well.

Looked this up. This works off the sigma-2 receptor. The sigma-1 receptor is stimulated by the following drugs: Cocaine, DXM(ie cough syrup), Methamphetamine, “some” opioids, ketamine, ritalin, PCP, DMT(the base molecule for psychedelic drugs and a very powerful hallucinogen in it’s own right). Hmmmm.

[prophetic]

Ok, so Big Pharma needs to make 25 yrs of profits off the suffering backs of the sheeple before they release this to the public and since it will only needs to be 1/6th the dosage then the pricing will be proportionality be 6x the cost.

Hey its simple economics to protect their profits.

[hadaclueonce]

Does it also keep one from pooping?

[Slyfox]

The study’s lead author, Stephen Martin

[WatchungEagle]

Found this gem on Wiki: "...some individuals find σ–receptor agonists euphoric with significant anti-depressive effects. Other individuals, however, experience dysphoria and often report feelings of malaise or anxiety." "Euphoric." That means high as hell. But some people get anxious and don't like it. Just like every other drug of abuse. My guess is this stuff feels like crack mixed with PCP.

[BipolarBob]

If you were dealing with severe pain every day you wouldn’t be so glib.

[Gahanna Bob]

Arena Pharmaceuticals (ARNA) has a non-opioid pain med in phase 2 clinical trial. Could be a blockbuster.

[Oystir]

could you disclose more, please?

[Fuzz]

“If you were dealing with severe pain every day you wouldn’t be so glib.”

Amen

[Gahanna Bob]

APD371, an orally available agonist of the CB2 receptor, is an internally discovered investigational drug candidate that Arena is exploring for potential development in several indications, including pain. This compound, through its selectivity, is designed to provide pain relief without psychotropic effects and without the potential for dependence or abuse.

Supposed to be more powerful than morphine according to stuff I’ve read.

More info at www.arenapharma.com

Full disclosure I’m a long suffering underwater shareholder.