The one issue might be getting Barron to school. But, with the ubiquity of electronic communications he could “attend” a class remotely at least some of the time.
The only issue would be that cabinet level people might have to relocate as I believe that Camp David is quite a ways away.
Another side benefit would be that if the Whitehouse were a museum and State banquet hall then the traffic around that area in DC could be simplified because some of the roads could be reopened. If Trump needed to get to DC then he’d just take a helicopter.
Barron is already going to school up in Potomac MD so maybe it would make sense to live up at Camp David. The President could drop him off by helicopter on the way to the White House.