I've heard people claim that the US Constitution forbids secession by any state, but I've never seen anyone cite the Article, Section, or Amendment which states this.
I'm not even going to ask that you do so. I'm just going to state the self evident truth that any people have the inalienable right to leave a political union they no longer wish to be part of. This is especially true of our (supposedly) sovereign states.
However, as I see it, there isn't any meaningful support for secession or revolution. The folks who signed the Declaration pledged their lives, their fortunes and their sacred honor. They played for keeps. There aren't ten thousand people in this country who are prepared to die over social issues like abortion or homosexual rights, or over economic issues like whether the highest marginal tax rate should be 35% or 39%, Obamacare, the Federal Reserve, etc.
If I were to become so unhappy with the USA that I couldn't take it anymore, I would emigrate rather than just sit here complaining.
Patience. Wait long enough and the pendulum will be swinging the other way.