Thomas Jefferson and John Adams
These men did neither disdain nor disrespect Christians.
Ridicule is the only weapon which can be used against unintelligible propositions. Ideas must be distinct before reason can act upon them; and no man ever had a distinct idea of the trinity. It is the mere Abracadabra of the mountebanks calling themselves the priests of Jesus.
And:
In our Richmond there is much fanaticism, but chiefly among the women. They have their night meetings and prayer parties, where, attended by their priests, and sometimes by a hen-pecked husband, they pour forth the effusions of their love to Jesus, in terms as amatory and carnal, as their modesty would permit them to use a mere earthly lover.
He's certainly showing disdain towards some Christians in regards to their Christianity, but I don't recall him ever doing so towards Christians in general.
Thomas Paine is another matter, or course...