I will vote for whichever of Perry or Hutchison who pledge to make this happen.
Perry seems more open to it. I have yet to hear anything from KBH about asserting Texas' sovereignty but I'm guessing she thinks it's a bad idea. It makes her present job harder.
If I were Perry, I'd run hard on an anti-Washington theme because it attacks KBH indirectly as "the candidate from Washington" and transitions into the general election against any Dem as "the candidate of Obama". That way, you brand your opponent with the over-reaching feds, which is bound to resonate with a majority of voters.
That's not to say I've been thrilled with either Perry or KBH to this point. Both are "okay" Republicans in my book but both have gone in directions that make me wince sometimes. They'd both get throttled by a Palin-type conservative.