One gun does not fit well for both Hunting and defense if you are talking medium to big game and home defense. A 308 for hunting would be too big for home defense. My home defense semi is the M1-carbine but I have varius other weapons for hunting.
I have a tactical Remington 870 12gauge for home defense...
so the 308 may be a fit.
HK USC .45 ACP carbine (the civilian UMP). If they’re more than 200 yds away I’m not worried. If they’re closer than 200 yds they’re cooked.