Experimental Agent Blocks Prostate Cancer In Animal Study

artorius castus blog ^ | 24 May 08 | Science Daily

[cardinal4]

An experimental drug has blocked the progression of prostate cancer in an animal model with an aggressive form of the disease, new research shows.

The agent, OSU-HDAC42, belongs to a new class of drugs called histone deacetylase (HDAC) inhibitors, compounds designed to reactivate genes that normally protect against cancer but are turned off by the cancer process.

[cardinal4]

More good news from the Cancer front. And Science Daily is a really cool website..

[cardinal4]

The agent, OSU-HDAC42, belongs to a new class of drugs called histone deacetylase (HDAC) inhibitors, compounds designed to reactivate genes that normally protect against cancer but are turned off by the cancer process.

I wonder if they are tweaking the mRNA messaging process?

[devane617]

I am currently battling Prostate Cancer. I look forward to the day when PCa, and all forms of cancer is eradicated.

[cardinal4]

You just got put on a prayer list. My Mom, a friend at work, and another relative all have cancer or have passed from it. I hate it, and join battle with you..

[devane617]

Until I started radiation treatments a few months ago, I had no idea how many people were effected by cancer. Going to the local cancer center each day for three months was an eye-opening experience. I thought I would see ‘old’ people, but to my surprise, and shock, the majority of people I saw each day were/are young.

[outofsalt]

Provenge, an immonutherapy which had a 33% survival as opposed to 11% for placebo, was delayed by the FDA last year even though an advisory committee voted 17-0 that it was safe and 13-4 that it was effective in prolonging life in the sickest patients. The FDA is broken! Protests are planned May 30th. www.caretolive.com

[cardinal4]

Alfacell shows promise, too. Its direction is to disrupt mRNA transcription in a cancer cell. That way the proteins needed for cancer cell division and metastisis are not produced..

[outofsalt]

Only one drug has been approved in the last 30 years to treat PC and that has harsh side effects. Alfacell’s studies are still years away as they are aimed at mesothelioma and lung cancer and will likely have to be re-trialled for PC. Provenge has completed enrollment in the 3rd phase three trial and should present interim results to the FDA later this year. The FDA wants more study even though these patients have no other real options.

[Luke21]

It’s likely I have it myself. My best to you and prayers for deliverance.

[devane617]

Luke21, If you have the symptoms and have not had a diagnoses, then do it now. A biopsy is simple, and not much more painful than a visit to the dentist, but the test is very necessary. Research you options, and move to a treatment. By the way, I have learned that cancer treatment is not only medicine, but big business. Lots of treatment options means lots of competition for your dollar. Be informed — that is the only way to get the best outcome for your particular situation.