More than half of all Americans are already vaccinated for Smallpox, though the lingering effectiveness of those old vaccinations is debatable.
As for Hoof and Mouth, pretty harmless...
Overview of Hoof and Mouth Disease (HMD)
Even though it has a low fatality rate, HMD is considered the world's most important animal disease. HMD affects all cloven-footed animals and is present in Africa, Asia, South America, and Europe. A good Web resource is found at http://aleffgroup.com/avisfmd/.
The current outbreak of the disease in the United Kingdom has brought considerable media attention. The previous most recent outbreak in the UK was in 1967-68. A devastating epidemic occurred in Taipei, China in 1997, when over four million pigs died or were slaughtered within two months. The last outbreak for the United States was 1929, in Canada was 1951-54, and in Mexico was 1946-54.
Horses are not susceptible to the disease. Humans are evidently slightly susceptible and may develop vesicles (or blisters) in the mouth or on hands. For more information: http://www.iah.bbsrc.ac.uk/virus/Picornaviridae/enterovirus/hfmd.htm. Cases of human infection are rare, even among people working with infected animals and materials.
The virus that causes HMD is easily and rapidly transmitted through air, infected meat and milk products, clothing, or other means by which the agent can be carried to the next host. It is estimated that sufficient virus to initiate an infection can be windborne as far as 150 miles. Pigs are the most potent excretors of airborne virus, and cattle the most susceptible to airborne infections. The virus has been found in the semen of bulls and boars, although transmission via embryos from infected cows has not been found to occur. Animals that have recovered from the disease can commonly continue to be carriers of the virus and remain infectious for as long as 6 months. The virus may persist for over one year on infected premises, for 12 weeks on clothing and feed, and for up to a month on hair.
The morbidity rate in outbreaks of HMD in susceptible animals can rapidly approach 100 percent, although the case fatality rate is generally less than two percent but slightly higher in younger animals.