In a decade of Sys Admin, I've never seen a program that needed an administrator account to function. I would view with very jaded eyes any program that required such.
It wrote to the registry, requiring admin access.
There are quite a few vertical solution applications that will not run on limited accounts. I work with optometrists, physicians, dentists, and chiropractors... and so far I have found most of the popular medical practice packages for small offices will not run in a limited account, insisting on full administrator mode. This leads to problems with successful attacks on their systems by viruses, ad-ware and spyware.