Our first trip in 1983 originated in Frankfurt where we started our Eurail adventure to Vienna for a few days, south to Venice for shopping and gawking, back north to Monte Carlo, Nice, and then to Geneva where Pam's sister's family lived.
We had no reservations for lodging so we could stay as long, or as short a time at any one stop. The only place my strategy proved weak was in Monte Carlo: turned out that we arrived around 12am during Grand Prix. Reservations during this week are like season tickets to the Packer's football games - they are so prized as to be mentioned in folk's wills! Yikes. So we reboarded the next train and continued on to Nice where lodging was secured.
Last October our neighbors spent a wonderful two weeks in Rome and are ready to return - there is that much to see and do in the Eternal City.
Whatever you do -pack LIGHTLY. All those duds you won't wear sure do start to weigh heavily upon the shoulders. You will have a wonderful time, guaranteed!