I have seen reports of an African lake that had such an erruption of methane.
They found the village with everyone and every animal dead.
That might happen with Seneca Lake.
People have homes right on the lake and the mountains rise rapidly as you move away from the water’s edge.
A large enough bubble could rapidly displace the oxygen near the surface of the lake and kill thousands in the summer when all of those summer homes are occupied.
Hobart and William Smith Colleges sit right at the Northern end. If it happened while school was in session the count of the dead could be huge.
Here is a little fun fact:
Hunter Biden has a tattoo of the Finger Lakes on his back.
According to Google AI:
“Yes, Hunter Biden has a large tattoo of New York’s Finger Lakes region across his back. He got the ink in honor of his mother, Neilia Hunter Biden, who grew up in the Skaneateles area—one of the lakes in the region”
I took my PADI-Scuba open water dive in Skaneateles Lake.
It is just to the west of Syracuse. Where I went to college.