Yes. As a matter of fact I use my same BOB/GHB when I hunt elk in Northern Arizona. My BOB/GHB is built around a medium ALICE pack. The only changes I make for hunting are to carry game bags, extra knives, more water and additional cold weather clothing. I'm confident with the system I have and have used it numerous time out in the wild.
For me, the medium ALICE is the best fit for how much weight I can reasonably carry all day.
A BOB should usually be totally emptied and restructured for the warm time of the year, and the cold time of the year, if you are packing light and right then one size fits all can’t be 100% optimum for either.