The biggest threat to the public out there is Chemical Shipments on rail.
East Palestine, Ohio is proof enough of that.
Shipping of High Level nuclear waste can be pretty safe in comparison.
I believe most of it WAS shipped on semi tractor trucks.
My dad drove for a company called Chemical Leaman tank lines. They were a trucking company that handled the shipment of various hazardous chemicals in stainless steel tankers. He was a CDL driver with an almost spotless record. Meaning, he had badges with no accidents in 500K miles, etc.
They shipped rocket propellant, blue indigo dye, raw sugar, jet fuel, Palmolive dish detergent, flammables and corrosives.
The only truckers that got paid higher than him were the truckers hauling nuclear waste. They had to have a spotless driving record. They also did not have a placard on the front of tractor or rear of the tank that says “nuclear waste”. It probably said “flammable” or “corrosive”. Obviously, they did not want to advertise they were hauling nuclear waste down I90.
My dad retired in around 1980. The trucking company he hauled for is no longer in business.
Dad passed about 29 years ago.