Replies

Year	Study / Authors	Journal / Source	Key Finding / Relevance	Reference URL
1935	Rich AR. "On the frequency of occurrence of occult carcinoma of the prostate."	Journal of Urology	⇨ Autopsy found occult prostate carcinomas in 14% of men; suggests dormant/suppressed cancers common in healthy people.	AUA Journals (Abstract/Full)
1949	Franks LM. "Latent carcinoma of the prostate."	Journal of Pathology and Bacteriology	⇨ Latent prostate cancer in 27% of autopsies over age 50; supports widespread suppressed microscopic tumors.	PubMed Search (Related Citations)
1953	Edwards CN et al. "An autopsy study of latent prostatic cancer."	Cancer	⇨ Occult prostate cancer in 13.4% of autopsies; implies biological/immune containment since clinical rates much lower.	Wiley Online Library (Abstract/Full)
1954	Franks LM. "Latent carcinoma of the prostate."	Journal of Pathology and Bacteriology	⇨ Up to 30–40% latent prostate cancer in older men at autopsy; host factors (including immunity) likely control progression.	PubMed Search (Related Citations)
1959	Thomas L. Discussion in Cellular and Humoral Aspects of the Hypersensitive States.	(Book chapter/discussion)	⇨ Early proposal of immune surveillance recognizing/eliminating nascent cancer cells; explains dormancy of occult tumors.	PMC Article (Historical Review Citing Thomas 1959)
1969	Sampson RJ et al. "Thyroid carcinoma in Hiroshima and Nagasaki..."	JAMA	⇨ Occult thyroid carcinoma in 28% of autopsies; latent cancers suppressed in vivo.	PubMed Search (Related Citations)
1970	Burnet FM. "The concept of immunological surveillance."	Progress in Experimental Tumor Research	⇨ Formalized immunosurveillance: immune system eliminates emerging cancer cells, preventing clinical disease from occult ones.	SCIRP Reference (Abstract/Citation)
1977	Breslow N et al. "Latent carcinoma of prostate at autopsy in seven areas."	International Journal of Cancer	⇨ 12–43% latent prostate cancer across countries; age increases prevalence; immune equilibrium implied over clinical rates.	PubMed Search (Related Citations)
1979	Sobrinho-Simões MA et al. "Latent thyroid carcinoma at autopsy..."	Cancer	⇨ Occult thyroid carcinoma in 6.5% of autopsies; mostly microcarcinomas kept dormant by surveillance.	PubMed Search (Related Citations)
1985	Harach HR et al. "Occult papillary carcinoma of the thyroid..."	Cancer	⇨ 35.6% occult papillary thyroid carcinomas in autopsies; nearly all in 50–70 age group; far exceeds clinical incidence → suppression.	Wiley Online Library (Abstract/Full)
1987	Nielsen M et al. "Breast cancer and atypia among young and middle-aged women..."	British Journal of Cancer	⇨ Histologic breast cancers in 39% of women in 40s at autopsy vs. 1% clinical; dormant lesions controlled by immunity.	PubMed Search (Related Citations)
1990	Yamamoto Y et al. "Occult papillary carcinoma of the thyroid..."	Cancer	⇨ 22.5% occult thyroid cancer in Japanese autopsies; small tumors suppressed in healthy individuals.	PubMed Search (Related Citations)
1993	Sakr WA et al. "The frequency of carcinoma and intraepithelial neoplasia of the prostate..."	Journal of Urology	⇨ In situ prostate carcinoma in 27–34% of men in 30s–40s; early dormant cancers immune-suppressed.	PubMed Search (Related Citations)
2007	Koebel CM et al. "Adaptive immunity maintains occult cancer in an equilibrium state."	Nature	⇨ Landmark: adaptive immunity holds occult cancer in equilibrium (dormancy) without full elimination; direct evidence in models + human relevance.	Nature (Abstract/Full)
2015	Bell KJ et al. "Prevalence of incidental prostate cancer: A systematic review..."	International Journal of Cancer	⇨ Meta-analysis: incidental prostate cancer 5% under 30 to 59% over 79; large latent reservoir implying suppression.	Wiley Online Library (Abstract/Full)
2017	Manjili MH. "Tumor Dormancy and Relapse..."	Cancer Research	⇨ Autopsy evidence of occult cancers in healthy people; dormancy due to immune equilibrium.	PubMed Search (Related Citations)
2021	Zidar N et al. "Global Trends of Latent Prostate Cancer in Autopsy Studies."	Cancers	⇨ Meta-analysis confirms age-related latent prostate cancer; supports immune suppression role.	PubMed Search (Related Citations)
2021	Damen MP et al. "Targeting dormant tumor cells..."	FEBS Journal	⇨ Dormant cells persist via immune equilibrium; autopsy data shows they are controlled.	PubMed Search (Related Citations)

Year Study / Authors Journal / Source Key Finding / Relevance Reference URL
1935 Rich AR. "On the frequency of occurrence of occult carcinoma of the prostate." Journal of Urology ⇨ Autopsy found occult prostate carcinomas in 14% of men; suggests dormant/suppressed cancers common in healthy people. AUA Journals (Abstract/Full)
1949 Franks LM. "Latent carcinoma of the prostate." Journal of Pathology and Bacteriology ⇨ Latent prostate cancer in 27% of autopsies over age 50; supports widespread suppressed microscopic tumors. PubMed Search (Related Citations)
1953 Edwards CN et al. "An autopsy study of latent prostatic cancer." Cancer ⇨ Occult prostate cancer in 13.4% of autopsies; implies biological/immune containment since clinical rates much lower. Wiley Online Library (Abstract/Full)
1954 Franks LM. "Latent carcinoma of the prostate." Journal of Pathology and Bacteriology ⇨ Up to 30–40% latent prostate cancer in older men at autopsy; host factors (including immunity) likely control progression. PubMed Search (Related Citations)
1959 Thomas L. Discussion in Cellular and Humoral Aspects of the Hypersensitive States. (Book chapter/discussion) ⇨ Early proposal of immune surveillance recognizing/eliminating nascent cancer cells; explains dormancy of occult tumors. PMC Article (Historical Review Citing Thomas 1959)
1969 Sampson RJ et al. "Thyroid carcinoma in Hiroshima and Nagasaki..." JAMA ⇨ Occult thyroid carcinoma in 28% of autopsies; latent cancers suppressed in vivo. PubMed Search (Related Citations)
1970 Burnet FM. "The concept of immunological surveillance." Progress in Experimental Tumor Research ⇨ Formalized immunosurveillance: immune system eliminates emerging cancer cells, preventing clinical disease from occult ones. SCIRP Reference (Abstract/Citation)
1977 Breslow N et al. "Latent carcinoma of prostate at autopsy in seven areas." International Journal of Cancer ⇨ 12–43% latent prostate cancer across countries; age increases prevalence; immune equilibrium implied over clinical rates. PubMed Search (Related Citations)
1979 Sobrinho-Simões MA et al. "Latent thyroid carcinoma at autopsy..." Cancer ⇨ Occult thyroid carcinoma in 6.5% of autopsies; mostly microcarcinomas kept dormant by surveillance. PubMed Search (Related Citations)
1985 Harach HR et al. "Occult papillary carcinoma of the thyroid..." Cancer ⇨ 35.6% occult papillary thyroid carcinomas in autopsies; nearly all in 50–70 age group; far exceeds clinical incidence → suppression. Wiley Online Library (Abstract/Full)
1987 Nielsen M et al. "Breast cancer and atypia among young and middle-aged women..." British Journal of Cancer ⇨ Histologic breast cancers in 39% of women in 40s at autopsy vs. 1% clinical; dormant lesions controlled by immunity. PubMed Search (Related Citations)
1990 Yamamoto Y et al. "Occult papillary carcinoma of the thyroid..." Cancer ⇨ 22.5% occult thyroid cancer in Japanese autopsies; small tumors suppressed in healthy individuals. PubMed Search (Related Citations)
1993 Sakr WA et al. "The frequency of carcinoma and intraepithelial neoplasia of the prostate..." Journal of Urology ⇨ In situ prostate carcinoma in 27–34% of men in 30s–40s; early dormant cancers immune-suppressed. PubMed Search (Related Citations)
2007 Koebel CM et al. "Adaptive immunity maintains occult cancer in an equilibrium state." Nature ⇨ Landmark: adaptive immunity holds occult cancer in equilibrium (dormancy) without full elimination; direct evidence in models + human relevance. Nature (Abstract/Full)
2015 Bell KJ et al. "Prevalence of incidental prostate cancer: A systematic review..." International Journal of Cancer ⇨ Meta-analysis: incidental prostate cancer 5% under 30 to 59% over 79; large latent reservoir implying suppression. Wiley Online Library (Abstract/Full)
2017 Manjili MH. "Tumor Dormancy and Relapse..." Cancer Research ⇨ Autopsy evidence of occult cancers in healthy people; dormancy due to immune equilibrium. PubMed Search (Related Citations)
2021 Zidar N et al. "Global Trends of Latent Prostate Cancer in Autopsy Studies." Cancers ⇨ Meta-analysis confirms age-related latent prostate cancer; supports immune suppression role. PubMed Search (Related Citations)
2021 Damen MP et al. "Targeting dormant tumor cells..." FEBS Journal ⇨ Dormant cells persist via immune equilibrium; autopsy data shows they are controlled. PubMed Search (Related Citations)